Protein Details: Potassium voltage-gated channel subfamily E member 2

Protein ID

ICDB_Pro_1723

Protein Name

Potassium voltage-gated channel subfamily E member 2

Gene Name

KCNE2

Organism

Homo sapiens (Human)

Length

123 amino acids

AlphaFoldDB

AF-Q9Y6J6-F1-model_v4.pdb

Function

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation;a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current. KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability

Sequence

MSTLSNFTQTLEDVFRRIFITYMDNWRQNTTAEQEALQAKVDAENFYYVILYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYIVEDWQEKYKSQILNLEESKATIHENIGAAGFKMSP

PDB Structures

2M0Q

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Atrial Fibrillation;Familial;4 and Long Qt Syndrome 6

Location

Highly expressed in brain; heart; skeletal muscle; pancreas; placenta; kidney; colon and thymus. A small but significant expression is found in liver; ovary; testis; prostate; small intestine and leukocytes. Very low expression; nearly undetectable; in lung and spleen.

DOI ID

10.1016/s0092-8674(00)80728-x; 10.1101/gr.2596504; 10.1016/s0014-5793(00)01918-9; 10.1093/emboj/19.23.6326; 10.1096/fj.01-0520hyp; 10.1002/jcp.22265; 10.1007/s00109-002-0364-0; 10.1086/425342; 10.1111/j.1399-0004.2006.00671.x; 10.1016/j.hrthm.2009.05.021

RefSeq

NP_751951.1